PhD Defended · 6 May 2026 · University of Sassari

Dr. Safeer
Ali Mirani

Computational Neuroscience·XR Visualisation·GPU Computing

I build GPU-accelerated visualisation systems for large-scale neural networks. The NeuroConstellation platform family renders up to 5.28M neurons across 5 platforms: desktop, mixed reality, virtual reality, and WebGPU browser.

Neurons rendered
XR / Web platforms
Published works
Countries
Scroll
About

Bridging neuroscience, GPU computing & immersive technology

I successfully defended my PhD in Life Sciences and Biotechnologies at the University of Sassari, Italy, on 6 May 2026. My doctoral research developed the NeuroConstellation platform family — five GPU-accelerated visualisation tools for rendering large-scale neural network activity across desktop, mixed reality, virtual reality, and web browser environments.

My work sits at the intersection of computational neuroscience, extended reality, and human-computer interaction. I collaborate with researchers at the Institute of Biophysics CNR Palermo (Migliore lab), George Mason University (Ascoli lab), EBRAINS-Italy, and Aix-Marseille University, where I completed a 6-month international research mobility from August 2025 to January 2026. My ongoing research includes EEG signal analysis using MATLAB and brain co-simulation frameworks within the EBRAINS-Italy infrastructure.

Before the PhD, I earned an M.S. in Software Engineering from UESTC, China — where my thesis focused on fine-grained emotion detection from text using deep learning — and a B.S. in Computer Science from the University of Sindh, Pakistan. This interdisciplinary background, combining software engineering, NLP, and neuroscience, shapes how I approach complex visualisation challenges.

Notable distinction: Part of the first group of international students invited to serve as museum guides in UESTC's 60-year history (2019), delivering special lectures on Chinese technological advancement to a global audience.

Outside research, I have been actively involved in community work — most notably as an ILM Ambassador with the British Council's Take a Child to School programme, which contributed to enrolling over 110,000 out-of-school children across Pakistan.

Research & Projects

The NeuroConstellation platform family

Five GPU-accelerated visualisation systems spanning desktop, mixed reality, virtual reality, and the open web — rendering neural activity at scales previously inaccessible to interactive exploration.

NeuroConstellation Desktop

2023 — 2026 · Chapter 4

GPU-accelerated desktop visualisation of large-scale neural network activity, including human hippocampal CA1 datasets. Six visualisation modes alongside parallel GPU-accelerated analysis (firing-rate maps, recruitment maps, spike-history trails); validated against a Python NumPy/SciPy reference pipeline.

Unity3D HLSL C# GPU Compute

HoloNeV — HoloLens 2

2024 — 2026 · Chapters 5 & 6

Mixed reality visualisation of mouse hippocampus CA1 neural activity on Microsoft HoloLens 2, using a distributed workstation–headset architecture for high-resolution rendering. Hand gesture interaction via Microsoft MRTK, with a novel proxy container interaction paradigm for manipulating dense neural datasets.

MRTK HoloLens 2 Hand Tracking Holographic Remoting

Immersive VR — Varjo XR-4

2025 — 2026 · Chapter 7

Stereoscopic VR visualisation of human hippocampus CA1 neural activity in Varjo XR-4 with Ultraleap hand tracking. Configurable dataset loading and confidence-based gesture interaction enabling six-degree-of-freedom manipulation in immersive space.

Varjo XR-4 Ultraleap Immersive VR Unity XR

NeuroConstellation Web

2026 · Chapter 8

Browser-based neural visualisation using WebGPU compute shaders. All six visualisation modes translated from HLSL to WGSL. Zero installation — runs in Chrome, Edge, Firefox, and Safari on any WebGPU-capable browser. Open-source release archived on Zenodo.

WebGPU WGSL JavaScript Browser-native
Open live demo

EEG Data Analysis

Ongoing

Signal processing pipelines using MATLAB for EEG data analysis, implementing machine learning algorithms for pattern recognition and brain state classification.

MATLAB EEGLAB Signal Processing

Brain Co-Simulation

Ongoing · EBRAINS-Italy

Co-simulation tasks integrating multiple brain modelling platforms to bridge different scales of neural organisation, in collaboration with EBRAINS-Italy.

EBRAINS-Italy Python Neuroscience

Emotion Detection from Text

2017 — 2019 · Master's Thesis

Fine-grained emotion classification using LSTM, CNN, and transformer architectures. Research conducted at UESTC NLP Lab.

PyTorch TensorFlow NLP

Sindh University Larkana Web Portal

2016 · Bachelor's Project

Final-year project officially adopted as the Sindh University Larkana Campus web portal. First prize in the departmental software project exhibition.

PHP SQL HTML/CSS

Live: NeuroConstellation Web

Try the browser-native version — million-scale neural visualisation running entirely on WebGPU compute shaders. No installation, no headset, just a modern browser.

Open in new tab

NeuroConstellation Web

Best experienced in a dedicated browser tab where WebGPU has full GPU access. Requires Chrome 113+, Edge 113+, Safari 18+, or Firefox 141+.

Launch demo
Publications

Research output

Core thesis publications, conference posters, and collaborative works.

Core Thesis Publications

5 papers

NeuroConstellation: Real-Time Visualisation and Analysis of Million-Neuron Datasets Using Game Engine Technology

Mirani, S.A., Memon, P., Enrico, P., & Solinas, S.M.G. (2025)

iScience · Chapter 4

Zenodo: 10.5281/zenodo.17650645
Ready for submission

HoloNeV: Advancing Human-Computer Interaction in Neuroscience Through Mixed Reality Neural Visualisation

Mirani, S.A., Memon, P., Enrico, P., Solinas, S.M.G., Bologna, L.L., Ali, M., & Migliore, M. (2025)

MDPI Electronics · Chapter 5

Ready for submission

Mixed Reality Visualisation of Mouse Hippocampus CA1 Neural Activity with Hand Gesture Interaction on Microsoft HoloLens 2

Mirani, S.A., Memon, P., Enrico, P., & Solinas, S.M.G. (2026)

Scientific Reports · Chapter 6

Ready for submission

Immersive Virtual Reality Visualisation of Human Hippocampus CA1 Neural Activity with Hand Tracking Interaction in Varjo XR-4

Mirani, S.A., Memon, P., Enrico, P., & Solinas, S.M.G. (2026)

Springer Nature Virtual Reality · Chapter 7

Ready for submission

NeuroConstellation Web: Real-Time Visualisation of Million-Scale Neural Activity via WebGPU Compute Shaders

Mirani, S.A., Memon, P., Enrico, P., & Solinas, S.M.G. (2026)

IEEE Transactions on Visualization and Computer Graphics · Chapter 8

Live demo

Conference Poster Presentations

2 posters
Poster · OCNS 2025

HoloNeV: Holographic Visualisation Tool for Neural Network Activity

Mirani, S.A., Memon, P., Migliore, M., Bologna, L.L., Ali, M., Enrico, P., & Solinas, S.M.G. (July 2025)

Organisation for Computational Neurosciences (OCNS), Florence, Italy

Poster · EBRAINS-Italy 2024

Holographic Visualisation of Neural Network Activity

Mirani, S.A., Enrico, P., & Solinas, S. (December 2024)

EBRAINS-Italy, Naples, Italy — GPU-accelerated indirect instancing on HoloLens 2

Collaborative Publications

3 works
Published

Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform

Ali, M., Smiriglia, R., Spera, E., Mirani, S.A., Solinas, S.M.G., Migliore, M., Ascoli, G.A., & Bologna, L.L. (2026)

Scientific Reports, 16, 14345 — Open Access · Published 20 March 2026

DOI: 10.1038/s41598-026-44588-0
Poster · OCNS 2025

Neural Circuit Visualizer: A Web-Based Platform for the Simulation and Visualisation of Full-Scale Point-Neuron Circuits

Ali, M., Smiriglia, R., Spera, E., Mirani, S.A., Solinas, S.M.G., Migliore, M., Ascoli, G.A., & Bologna, L.L. (July 2025)

Organisation for Computational Neurosciences (OCNS), Florence, Italy

Published

The Evaluation and Comparative Analysis of Role Based Access Control and Attribute Based Access Control Model

Aftab, M.U., Qin, Z., Zakria, Ali, S., Pirah, & Khan, J. (2018)

15th ICCWAMTIP, pp. 35–39

DOI: 10.1109/ICCWAMTIP.2018.8632578
Experience

Professional experience

Oct 2023 — May 2026 University of Sassari, Italy

PhD Researcher — Computational Neuroscience

Neural Network Visualisation & AI

  • Developed the NeuroConstellation platform family — five GPU-accelerated visualisation tools across desktop, HoloLens 2 (static and dynamic), Varjo XR-4, and WebGPU browser, rendering up to 5.28M neurons.
  • Collaborated with EBRAINS-Italy, CNR Palermo (Migliore lab), George Mason University (Ascoli lab), and Aix-Marseille University on neuroscience visualisation tools.
  • Implemented XR solutions using MRTK and Ultraleap hand tracking for scientific data visualisation.
  • Completed 6-month international research mobility at the Institut de Neurosciences des Systèmes (INS), Aix-Marseille Université, France (Aug 2025 — Jan 2026), hosted by Dr. Pierpaolo Sorrentino — working on Fano-factor analysis of recurrent network dynamics on the Galileo100 HPC cluster (CINECA).
  • Successfully defended doctoral thesis on 6 May 2026.
Jan 2022 — Jun 2022 SZABIST-ZABTech, Pakistan

Monitoring & Evaluation Officer

Educational Programme Management

  • Managed comprehensive data collection and analysis for technical and vocational education programmes.
  • Conducted Training of Trainers (ToT) workshops and Enterprise Development Sessions.
  • Implemented quality assurance frameworks and developed monitoring dashboards using Python and Excel.
Jul 2021 — Nov 2021 AKUEB, Pakistan

Quality Assurance Spot Checker

Examination Quality Control

  • Conducted spot checks across multiple examination centres during Annual and Re-sit 2021 sessions.
  • Identified and resolved procedural discrepancies, maintaining compliance with AKUEB protocols.
2017 — 2019 UESTC, China

Research Assistant — NLP Lab

Machine Learning Research

  • Developed deep learning models for emotion detection from text using LSTM, CNN, and transformer architectures.
  • Implemented NLP pipelines using Python, TensorFlow, and PyTorch.
  • Co-authored published paper on Role-Based vs Attribute-Based Access Control models.
2015 HBL Bank Pakistan

IT Intern

Banking Technology Department

  • Assisted in development of internal banking applications using Java and SQL.
  • Gained experience with enterprise-level IT infrastructure and security protocols.
Skills

Technical expertise

3D & XR Development

Unity3D MRTK HoloLens 2 Varjo XR-4 Meta Quest 3 Ultraleap WebGPU WGSL HLSL

Programming

Python C# C++ JavaScript MATLAB Java PHP SQL HTML/CSS

AI & Machine Learning

Deep Learning PyTorch TensorFlow Keras NLP Computer Vision EEGLAB MNE-Python

Tools & Platforms

Git/GitHub Docker Linux LaTeX Jupyter VS Code EBRAINS-Italy SPSS AMOS
Education

Academic journey

PhD in Life Sciences and Biotechnologies

2023 — 2026 · Defended 6 May 2026

University of Sassari (UNISS), Italy

Thesis: Real-Time Visualisation of Large-Scale Neural Networks: GPU-Accelerated Methods for Desktop, Extended Reality, and Browser Platforms.
Supervisors: Prof. Sergio M. G. Solinas and Prof. Paolo Enrico (Department of Biomedical Sciences).
International mobility (completed): Institut de Neurosciences des Systèmes (INS), Aix-Marseille Université, France (Aug 2025 — Jan 2026).

M.S. in Software Engineering

2017 — 2019 · GPA 3.57/4.00

University of Electronic Science and Technology of China (UESTC)

Thesis: Fine-Grained Emotion Detection from Text using Deep Learning. Specialisation in Machine Learning, NLP, and Software Architecture.

B.S. in Computer Science

2013 — 2016 · GPA 3.66/4.00

University of Sindh, Pakistan

Focus: Software Development, Database Systems, Web Technologies. First prize in Final Year Software Project Exhibition.

Intermediate (Pre-Engineering)

2010 — 2012 · Grade B (62.27%)

New Banat High School, BISE Hyderabad

Matriculation (Science)

2007 — 2009 · Grade A (70.23%)

The Best Academy, BSE Karachi

Certifications

Professional certifications & training

Certified AI Developer

Presidential Initiative for AI & Computing (PIAIC)
2024

Deep Learning with PyTorch: GAN

Coursera
2021

ML Pipelines with Azure ML Studio

Coursera
2021

Neural Style Transfer

Coursera
2021

AI for Everyone

DeepLearning.AI
2020

Data Science Fundamentals

Corporate Finance Institute (CFI)
2021

Scientific Writing Course

Multiomics
2023

Creative Writing

DigiSkills.pk
2022

Virtual Assistant Course

DigiSkills.pk
2022

Freelancing Course

DigiSkills.pk
2022

Social Media Marketing

HP LIFE
2021

Effective Presentations

HP LIFE
2021

PCAP: Programming Essentials in Python

Cisco Networking Academy
2022

NDG Linux Essentials

Cisco Networking Academy
2022

Python Programming Basics

Huawei
2021

Math Basics

Huawei
2021

Innovation Practice of IoT

Huawei
2021

Diploma in Web Development

Icon Institute, Larkana
2016

Certificate in IT (CIT)

DotCom Institute / BBSYDP
2013

Computer Hardware & Repairing

Educator Computer Institute
2010
Recognition

Awards, honours & recognitions

Academic Excellence

Academic Achievement Award

2018 · UESTC

Third prize for outstanding academic research performance

Excellent Performance Award

2018 · UESTC

Second prize for excellence in arts, sports, and voluntary work

Best Senior Ever Award

2017 · University of Sindh

Recognition for leadership and academic excellence

Software Project Exhibition

2017 · University of Sindh

First prize in Final Year software project exhibition

Prime Minister Laptop Scheme

2015

Awarded laptop for exceptional academic performance

Certificate of Performance

2015 · University of Sindh

Outstanding performance during bachelor studies

Sports & Cultural Achievements

Tour of Sichuan Athlete

2019

International Cycling Competition

Volleyball Champion

2018

Muslim Students Spring Sports — UESTC

Cricket Winner

2018

UESTC Summer Sports

Cricket Tournament Winner

2018

Muslim Student Spring Sport Activities

Outstanding Performance

2018

Cultural Activities at UESTC

Passion in Electronic Science

2018

Electronic Museum Award — UESTC

International Students Olympics

2018

Winter Inter-Dormitory Olympics

Appreciation Certificate

2015 · University of Sindh

Organising seminars and cultural events

Workshops

Workshops & specialised training

The Predictive Role of Connected Dynamical Systems

January 2026 · Online

Workshop organised by F. de Pasquale & S. Della Penna

environMENTAL Summer School

October 2025 · Marseille, France

Environmental & Computational Neuroscience, Aix-Marseille University

1st EBRAINS-Italy School (BRANDY)

September 2025 · Ala Birdi, Italy

BRAin DYnamics Academy

2nd Deep Learning Workshop

2018 · UESTC

School of International Education

IEEE COMSOC Summer School

2017 · Lahore, Pakistan

UET Lahore & FAST University with IEEE

Personal Development Workshop

2018 · UESTC, China

Build your Skills, Knowledge, Abilities (SKAs)

1st Sindh Youth Summit

2017 · Pakistan

Sports & Youth Affairs Department, Government of Sindh

Data Analysis using SPSS & AMOS

2016 · University of Sindh

Statistical analysis training

Community

Community service & volunteer leadership

VIP Member · Green Manor Club

2018–2019 · UESTC

Environmental and cultural organisation

ISU Election Officer

2018 · UESTC

International Students Union elections management

Cultural Exchange Volunteer

2018 · Shuangbai Community, Chengdu

Community-building activities

Conference Organiser

2018 · Chengdu

China Soft Conference 2018

Forum Volunteer

2018 · UESTC

40th Anniversary of China's Reform Forum

Welcome Committee

2018 · UESTC

International Freshers' Orientation

Study in UESTC Ambassador

2017 · UESTC

Promotional interviews for international education

Winter Cleaning Volunteer

2019 · UESTC

International Students Union initiative

Languages

Languages

English

Professional

Sindhi

Native

Urdu

Native

Italian

Elementary

Chinese

Elementary (HSK 1)
Contact

Let's collaborate

Open to postdoctoral positions, research collaborations, and consulting opportunities in computational neuroscience, XR, and GPU-accelerated visualisation.